Primary Intradural Extramedullary Ewing Sarcoma of the Thoracic Spine With Leptomeningeal and Brain Metastases: A Case Report and Literature Review

Muchsin, Achmad Harun (2026) Primary Intradural Extramedullary Ewing Sarcoma of the Thoracic Spine With Leptomeningeal and Brain Metastases: A Case Report and Literature Review. Brain Tumor Research and Treatment, 102 (108). pp. 2288-2413. ISSN 2288-2413

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Abstract

A 43-year-old woman presented with bilateral lower extremity weakness due to an intradural extramedullary
spinal cord tumor. Surgery revealed Ewing sarcoma, a rare presentation known as primary
intradural extramedullary Ewing sarcoma (PIEES). Despite initial treatment with radiation and chemotherapy,
tumor recurrence occurred after 17 months. Further interventions included additional surgery,
radiation, and chemotherapy. The disease progressed to leptomeningeal metastases along the spinal
cord, prompting various treatments including targeted spinal radiation and systemic therapies. Brain
metastases subsequently developed, necessitating whole-brain radiation and intrathecal chemotherapy.
This case highlights the aggressive nature of PIEES, its potential for widespread leptomeningeal
metastasis, and the challenges in its management, underscoring the need for multidisciplinary approaches
in treating this rare and aggressive malignancy.

Item Type:	Article
Uncontrolled Keywords:	Primary intradural extramedullary Ewing sarcoma; Ewing sarcoma; Leptomeningeal metastases.
Subjects:	600 Teknologi dan Ilmu Terapan > 610 Ilmu Kedokteran, Ilmu Pengobatan dan Ilmu Kesehatan R Medicine > R Medicine (General)
Depositing User:	Admin Admin
Date Deposited:	09 Jul 2026 07:24
Last Modified:	09 Jul 2026 07:24
URI:	http://192.168.168.84/id/eprint/8226

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