Antibakteri Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) terhadap Klebsiella pneumoniae Penghasil ESBL

Rivaldy, Naufal and Kartika, Andy Visi and Karim, Marzelina and Sodiqah, Yani and Anggita, Dwi (2025) Antibakteri Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) terhadap Klebsiella pneumoniae Penghasil ESBL. Jurnal Ilmiah Kesehatan (JIKA), 97 (3). pp. 709-706. ISSN 2686-2883

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Official URL: https://salnesia.id/jika/article/view/1560/665

Abstract

The rising prevalence of infections caused by Extended-Spectrum Beta-Lactamase (ESBL)-producing Klebsiella pneumoniae necessitates the search for alternative antibacterial agents. Red dragon fruit (Hylocereus polyrhizus) peel is a potential source of bioactive compounds. This study aimed to evaluate the in vitro antibacterial activity of red dragon fruit peel extract against ESBL-producing K. pneumoniae. The bacteria were isolated and identified via culture on MacConkey agar, Gram staining, and biochemical tests. The peel was extracted using 96% ethanol via maceration. Antibacterial activity was assessed using the disk diffusion method on Mueller-Hinton agar with extract concentrations of 20%, 40%, 60%, 80%, and 100% (v/v), with three replicates per concentration. Meropenem (10 μg) and DMSO served as positive and negative controls. The extract exhibited concentration-dependent antibacterial activity, with mean inhibition zone diameters increasing from 5,6 ± 0,3 mm at 20% to 6,1 ± 0,2 mm at 100%. The positive control produced a 30,2 ± 0,5 mm zone, while the negative control showed no inhibition. One-way ANOVA confirmed significant differences between groups (p-value < 0,05). Red dragon fruit peel extract demonstrated promising in vitro antibacterial activity against ESBL-producing K. pneumoniae, although its potency was considerably lower than meropenem.

Item Type:	Article
Uncontrolled Keywords:	Hylocereus polyrhizus, Klebsiella pneumoniae, bioactive compounds
Subjects:	600 Teknologi dan Ilmu Terapan > 610 Ilmu Kedokteran, Ilmu Pengobatan dan Ilmu Kesehatan R Medicine > R Medicine (General)
Divisions:	FAKULTAS KEDOKTERAN
Depositing User:	Admin Admin
Date Deposited:	09 Jun 2026 05:20
Last Modified:	09 Jun 2026 05:20
URI:	http://192.168.168.84/id/eprint/8211

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