Fatty acid-heterocyclic hybrids from green algae as novel therapeutic prospects for diabetes management

Bamahry, Aryanti R. and Ardiansyah, Abdul Mubdi and Safitri, Asrini and Rampengan, Derren David Christian Homenta and Syahputra, Rony Abdi and Taslim, Nurpudji Astuti and Santini, Antonello and Vencio, Sergio and Nurkolis, Fahrul (2025) Fatty acid-heterocyclic hybrids from green algae as novel therapeutic prospects for diabetes management. https://link.springer.com/article/10.1007/s44187-025-00636-8, 5 (1). pp. 1-42. ISSN 2731-4286

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Abstract

Diabetes mellitus is a major global health concern, driven by insulin dysfunction, oxidative stress, and chronic inflammation. Current treatments often have side effects, prompting interest in natural alternatives. Green algae have emerged as a promising source of fatty acid-heterocyclic hybrids—bioactive compounds with improved bioavailability, cell permeability, and multi-target antidiabetic activity. This review highlights their structural features, biosynthesis, extraction, and analysis, along with key mechanisms of action, including enzyme inhibition (α-glucosidase, α-amylase), modulation of insulin signaling (AMPK, PI3K/Akt), antioxidant and anti-inflammatory effects, and beta-cell protection. While preclinical results are promising, further research is needed to standardize activity, enhance bioavailability, and validate efficacy through clinical studies. Fatty acid-heterocyclic hybrids from green algae offer a novel and promising approach to diabetes management.

Item Type:	Article
Uncontrolled Keywords:	Green algae, Fatty acid, Diabetes, Antidiabetic agents, Insulin resistance, Bioactive marine compounds, Oxidative stress
Subjects:	600 Teknologi dan Ilmu Terapan > 610 Ilmu Kedokteran, Ilmu Pengobatan dan Ilmu Kesehatan R Medicine > R Medicine (General)
Divisions:	FAKULTAS KEDOKTERAN
Depositing User:	Admin Admin
Date Deposited:	04 Jun 2026 06:31
Last Modified:	04 Jun 2026 06:35
URI:	http://192.168.168.84/id/eprint/8198

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