UJI AKTIVITAS ANTIKOLESTEROL EKTRAK ETANOL KULIT JERUK BALI (Citrus maxima)

Pinaringsih, Ririn and Emelda, Andi and Widiastuti, Harti (2024) UJI AKTIVITAS ANTIKOLESTEROL EKTRAK ETANOL KULIT JERUK BALI (Citrus maxima). Other thesis, Universitas Muslim Indonesia.

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Abstract

RIRIN PINARINGSIH., 2023., Uji Aktivitas Antikolesterol Ekstrak Etanol
Kulit Jeruk Bali (Citrus Maxima) (Dibimbing oleh apt. Andi Emelda, S.Si.,
M.Si. dan apt. Harti Widiastuti, S.Farm., M.Farm).
Dampak yang terjadi jika kolesterol total dalam darah tinggi dapat
mengakibatkan hiperkolesterol dan jika berlanjut dalam waktu lama
memicu timbulnya hipertensi, stroke, jantung koroner, dan obesitas. Salah
satu tumbuhan yang berpotensi sebagai antikolesterol adalah kulit jeruk
bali (Citrus maxima). Kulit jeruk bali (Citrus maxima) memiliki kandungan
kimia seperti alkaloid, flavonoid, dan tannin. Penelitian ini bertujuan untuk
menentukan aktivitas antikolesterol ekstrak etanol kulit jeruk bali (Citrus
maxima) secara in vitro serta menentukan nilai EC50. Sampel diekstraksi
dengan metode maserasi menggunakan pelarut etanol 96% dengan
persen rendamen ekstrak 12,3%. Ekstrak yang diperoleh dianalisis
aktivitas antikolesterol dengan metode Lieberman-Burchard dengan
menggunakan pengukuran spektrofotometer UV-Vis dengan panjang
gelombang maksimum 623 nm. Hasil penelitian menunjukkan ekstrak
etanol kulit jeruk bali (Citrus maxima) memiliki aktivitas antikolesterol
secara in vitro. Nilai EC50 ekstrak etanol kulit jeruk bali (Citrus maxima)
yaitu sebesar 469,40 ppm.
Kata Kunci : Antikolesterol, Kulit jeruk bali, Spektrofotometere, Ekstrak
etanol

ABSTRACT
RIRIN PINARINGSIH. Anticholesterol Assay of Ethanol Extract of Pomelo
Peel (Citrus maxima). (Supervised by Andi Emelda and Harti Widiastuti)
Elevated total cholesterol levels in the bloodstream pose significant
health risks, including hypercholesterolemia, hypertension, stroke,
coronary heart disease, and obesity. Natural remedies, particularly plantbased
solutions, offer potential therapeutic benefits. The pomelo (Citrus
maxima), with its rich chemical composition, including alkaloids,
flavonoids, and tannins, presents a viable candidate for natural
cholesterol-lowering interventions. This study employed the in vitro
analysis to examine the anticholesterol activity from the ethanol extract of
pomelo peel and determine the EC50 value. The research employed a
maceration extraction technique using 96% ethanol, yielding a 12.3%
extract. The cholesterol-lowering activity of this extract was analyzed using
the Lieberman-Burchard method. Quantitative assessment was facilitated
by UV-Vis, focusing on the maximum absorbance at 623 nm. The results
indicated that the ethanol extract of pomelo peel exhibited significant
cholesterol-lowering activity by in vitro analysis and the EC50 value was
469.40 ppm, highlighting its potential efficacy.
Keywords: Anticholesterol, Citrus maxima Peel, Spectrophotometry,
Ethanol Extract

Item Type:	Thesis (Other)
Subjects:	L Education > L Education (General) Q Science > Q Science (General) R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	FAKULTAS FARMASI
Depositing User:	operator 10
Date Deposited:	10 Oct 2024 03:29
Last Modified:	10 Oct 2024 03:29
URI:	http://192.168.168.84/id/eprint/7043

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